Chemical Formula: C19H20N4O3S2 Exact Mass: 416.0977 Molecular Weight: 416.514 Elemental Analysis: C, 54.79; H, 4.84; N, 13.45; O, 11.52; S, 15.39 Synonym: T16Ainh-A01 T16Ainh A01 T16AinhA01 T16A(inh)-A01 T16A(inh) A01 T16A(inh)A01 Chemical Name: 2-[(5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]-acetamide InChi Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N InChi

Inhibering av ANOl med CaCCinh-A01, T16Ainh-A01 eller Ani9 minskar levande celltal på en dosberoende eller tidsberoende sätt. d-f stapeldiagram som visar

These Cl(-) currents were again potentiated with the addition of Tg, but inhibited in the presence of T16Ainh-A01. Finally, acinar cells isolated from the submandibular glands of TRPC1 knockout mice showed significant inhibition of the outward Cl(-) currents without decreasing TMEM16a expression. Effects of the Calcium-Activated Chloride Channel Inhibitors T16Ainh-A01 and CaCCinh-A01 on Cardiac Fibroblast Function August 2018 Cellular Physiology and Biochemistry 49(2):706-716 2015-07-01 2019-01-01 2018-10-02 T16AInh-A01 Gene Set. From CTD Gene-Chemical Interactions. genes/proteins interacting with the chemical T16AInh-A01 from the curated CTD Gene-Chemical Interactions dataset. AR-A014418-7070 Gene Set. From CMAP Signatures of Differentially Expressed … 2020-05-01 TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.

MONNA and T16Ainh -A01 also increased coronary flow in Langendorff perfused rat heart preparations. TMEM16A mRNA was increased in coronary artery smooth muscle cells from SHRs, and U46619 and 5-HT were more potent in arteries from SHRs than in those from normal Wistar rats. T16Ainh-A01 is a selective TMEM16A calcium-activated chloride channel inhibitor that strongly inhibits chloride current in salivary gland cells. T16Ainh-A01 poorly inhibited total CaCC current in intestinal and airway epithelial cells, but blocked mainly an initial, agonist-stimulated transient chloride current. T16Ainh - A01 Ca 2+ -activated Cl - channel transmembrane protein 16A (TMEM16A) inhibitor CAS# 552309-42-9 Catalog No. BCC6220 ----Order now to get a substantial discount! The effect of T16Ainh-A01 (1–30 μM) was studied on IClCa evoked by 500 nM free Ca2+. Applications.

Background and Purpose T16Ainh‐A01, CaCCinh‐A01 and MONNA are identified as selective inhibitors of the TMEM16A calcium‐activated chloride channel (CaCC). The aim of this study was to examine the c

Articles of T16Ainh-A01 are included as well. Structure, properties, spectra, suppliers and links for: t16ainh-a01, 552309-42-9.

CAS: 552309-42-9: Molecular Formula: C19H20N4O3S2: Molecular Weight (g/mol) 416.514: InChI Key: QSIYTNYMBWYHAA-UHFFFAOYSA-N: Synonym: t16a inh-a01,t16ainh-a01,2-5-ethyl-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl thio-n-4-4-methoxyphenyl thiazol-2-yl acetamide,2-5-ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl thio-n-4-4-methoxyphenyl-2-thiazolyl acetamide,2-5-ethyl-4-hydroxy-6-methylpyrimidin-2

176 previously reported to target human and/or mouse TMEM16A [44-46], whereas 13 May 2014 inhibitor T16Ainh-A01. Knockdown of ANO1 mRNA or incubation with a selective inhibitor T16Ainh-. A01 enhanced estradiol production, 25 Jul 2016 Our results therefore demonstrate that T16Ainh-. AO1 is acting on the calcium- dependent chloride channel in pancreatic acinar cells, and, 2 Jan 2018 In MCF7 and MDA-MB-231 breast carcinoma cells, inhibition of ANO1 with T16Ainh-A01 or siRNA for ANO1 significantly suppressed the 21 Apr 2015 ANO1 antagonist, T16Ainh-A01 (A01), in the presence of a high A01. Furthermore, pain-related behaviors in mice treated with cap- saicin 22 Jul 2014 ANO1 inhibitors (T16Ainh-A01, CaCCinh-A01, and NS3728), we found that ANO1 is the main constituent of CaCC current in PDAC cells. 28 Feb 2016 The specific ANO1 inhibitor T16Ainh-A01 also dose-dependently inhibited the 5- HT-induced contraction of mPA but had no effect on the KCl- T16Ainh - A01. Ca2+-activated Cl- channel transmembrane protein 16A ( TMEM16A) inhibitor.

T16Ainh-A01 new featured WARNING: This product is for research use only, not for human or veterinary use. MedKoo CAT#: 555877 CAS#: 552309-42-9 T16Ainh-A01 showed a marked inhibitory effect on the mRNA levels of ANO1 and α-SMA, but had a negligible effect on ANO1 at the protein level. T16Ainh-A01 and CaCCinh-A01 led to the significant repression of cell proliferation, cell migration, and collagen secretion in CFs. T16Ainh - A01, Tocris Bioscience 10mg Chemicals:Organic Compounds:Organic nitrogen compounds:Organonitrogen compounds:N-arylamides Background and Purpose T16Ainh‐A01, CaCCinh‐A01 and MONNA are identified as selective inhibitors of the TMEM16A calcium‐activated chloride channel (CaCC). The aim of this study was to examine the c View and buy high purity T16Ainh - A01 from Tocris Bioscience. Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor. Cited in 8 publications.
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C19H20N4O3S2.

T16Ainh-A01 new featured WARNING: This product is for research use only, not for human or veterinary use. MedKoo CAT#: 555877 CAS#: 552309-42-9 Description: T16A(inh)-A01 is an aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM.
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T16Ainh-A01 showed a marked inhibitory effect on the mRNA levels of ANO1 and α-SMA, but had a negligible effect on ANO1 at the protein level. T16Ainh-A01 and CaCCinh-A01 led to the significant repression of cell proliferation, cell migration, and collagen secretion in CFs.

Anoctamin-1 and bestrophin-1 mRNA and protein were expressed in the dorsal spinal cord and DRG of naïve, sham and neuropathic rats. The effect of pretreatment of HNECs with T16Ainh-A01, a specific inhibitor of TMEM16A, was investigated to determine if EGF-induced increase in MUC5AC expression was mediated by TMEM16A As shown in Fig. 3, pretreatment of the HNECs from CRSwNP patients with T16Ainh-A01 (10 μM) for 30 min before incubation with EGF 100 ng/ml significantly inhibited the EGF-induced increase in MUC5AC mRNA and In contrast, T16Ainh-A01 did not alter depolarization-induced (60 mM K(+)) vasoconstriction.

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Structure, properties, spectra, suppliers and links for: t16ainh-a01, 552309-42-9.

Effects of the Calcium-Activated Chloride Channel Inhibitors T16Ainh-A01 and CaCCinh-A01 on Cardiac Fibroblast Function T16Ainh-A01 treatment also led to a modest reduction in HRSV-G expression in the PCLS at 20 µM (figure 8E, representative blot) further confirmed through the assessment of HRSV-nucleoprotein (N) expression that similarly decreased following treatment with T16Ainh-A01 (20 µM). Effect of T16Ainh-A01 in isometric tension recordings from murine TA. Representative effects of 1 μM and 10 μM T16Ainh-A01 (A), niflumic acid (10–100 μM, B) and equivalent DMSO on TA pre ChemScene Provide T16Ainh-A01(CAS 552309-42-9)In-stock or Backordered impurities,Bulk custom synthesis,Formular C19H20N4O3S2,MW 416.52 bulk manufacturing, sourcing and procurement. and T16Ainh-A01, a selective ANO1 inhibitor, in high EGTA, a Ca2+ chelator. The voltage-dependent component disappears due to VGCC inhibition, suggesting that Ca2+ is the essential trigger for ANO1. In perforated current-clamping method, the application of T16Ainh-A01 and reduction of T16Ainh-A01 is a selective inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells).